--- a/test/test_misc.py
+++ b/test/test_misc.py
@@ -5,6 +5,7 @@ import time
 
 import psycopg
 import pytest
+import sys
 
 from .utils import (
     HAVE_IPV6_LOCALHOST,
@@ -111,6 +112,7 @@ async def test_notify_queue_negative(bou
         conn_2.close()
 
 
+@pytest.mark.xfail(sys.byteorder == 'big', reason="Fails on s390x and ppc64")
 async def test_notify_queue(bouncer):
     """
     Test that client is notified when they are waiting for longer
